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Comprehensive Analysis of Hypermutation in Human Cancer

2017· article· en· 796 citations· W2767034994 on OpenAlex· 10.1016/j.cell.2017.09.048

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.018
GPT teacher head0.301
Teacher spread
0.284 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Cell
Topic
Cancer Genomics and Diagnostics
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
Ontario GenomicsUniversity of ManitobaResearch Institute in Oncology and HematologyUniversity of TorontoSickKids FoundationUniversité LavalHospital for Sick ChildrenMount Sinai HospitalCancerCare Manitoba
Funders
National Cancer InstituteGarron Family Cancer CentreUniversity of TorontoNational Institute of Environmental Health SciencesSick Kids FoundationCanadian Institutes of Health ResearchHospital for Sick ChildrenGovernment of Ontario
Keywords
Somatic hypermutationBiologyGeneticsGermline mutationContext (archaeology)Microsatellite instabilityDNA repairMutationGermlineDNA mismatch repairCancer researchMicrosatelliteDNAGene
Has abstract in OpenAlex
no