MNGI-08. HIGH-RISK MENINGIOMA: INITIAL OUTCOMES FROM NRG ONCOLOGY/RTOG-0539
Bibliographic record
Abstract
Initial analysis of high-risk meningioma on NRG Oncology/RTOG-0539, outlining 3yPFS, overall survival (OS) and adverse events (AEs) This phII trial apportioned patients to 1 of 3 risk groups and management strategies by WHO grade, recurrence status, and resection extent. High-risk included newly diagnosed or recurrent WHOIII or recurrent WHOII of any resection extent, or newly diagnosed WHOII with subtotal resection (STR). Pathology and imaging were centrally reviewed. Patients were treated with RT, 60 Gy/30. 53 received protocol therapy, 28 (52.8%) female. 22 (41.5%) were WHOIII, 8 (15.1%) recurrent WHOII, 11 (20.8%) newly diagnosed WHOII after STR, and 12 (22.6%) imaging progression of prior WHO II/III meningioma. Median FU was 4.0y, 4.8y for living patients. 3yPFS was 58.8% comparable to literature-based estimate, 50% (p=0.13). 3yLC was 68.9%, and 3yOS 78.6%. 5yPFS, LC, and OS were 47.2, 62.4, and 59.1%. Among 51 evaluable for 3yPFS, there were 21 PFS events within 3y: 16 (31.4%) true progressors, and 5 (9.8%) who died without progression. These included 6 of 17 (35.3%) new WHOIII, 3 of 5 (60%) recurrent WHOIII, 4 of 7 (57.1%) recurrent WHOII, 3 of 11 (27.3%) new WHOII, and 5 of 11 (45.5%) with progressive tumor identified by imaging. Combined acute and late AEs (definitely, probably or possibly related to protocol treatment) included 1 (1.9%) grade 5 necrosis-related event. All others were grade 1-3: highest grade 1 in 13 (24.5%), 2 in 24 (45.3%), and 3 in 6 (11.3%). Patients with high-risk meningioma treated with RT experienced 3yPFS 58.8%. Acute and late AEs were limited to grades 1-3, excepting a single necrosis-related grade 5 event. These results support post-operative IMRT for WHOIII, recurrent WHOII, or newly diagnosed subtotally resected WHOII meningioma. They also confirm suboptimal outcome for this cohort, and strongly support further investigations to optimize management.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".