NCOG-01. PATIENT-REPORTED COGNITIVE CONCERNS AND QUALITY OF LIFE IN BRAIN METASTASES
Bibliographic record
Abstract
While treatment options for brain metastases continue to evolve, prognosis remains poor for morbidity and survival. Quality of life (QOL) is increasingly emphasized and assessed via patient-reported outcomes. Although studies show most patients are cognitively impaired on objective testing, few have explored patients’ subjective cognitive concerns in relation to other aspects of QOL. A cross-sectional sample of brain metastasis patients completed measures assessing subjective cognitive functioning in multiple domains as well as functional limitations, illness intrusiveness (i.e., interference in valued activities and relationships), existential distress, anxiety and depression. Seventy patients completed the survey; 40% were treated with SRS alone, 19% with WBRT±SRS, 7% with surgery and/or focal radiation only, and 34% had not yet received CNS-directed therapy. Patients ranged in age from 31-87; 64% were female. Prevalence of self-reported cognitive impairments varied by domain, with attention and processing speed most common (19% of patients each), followed by executive, memory and language functions (14, 11 and 9%). These cognitive concerns did not relate to patients’ age or differ by sex, but were associated with symptoms of anxiety (r’s = 0.365 to 0.527, p’s < .005), depression (r’s = 0.508 to 0.650, p’s < .001), existential distress (r’s = 0.338 to 0.541, p’s < .01) and illness intrusiveness (r’s = 0.333 to 0.442, p’s < .05). Processing speed and attentional deficits were additionally linked to limitations in instrumental activities (r’s = 0.262 and 0.272, p’s < .05). Patients who had undergone surgery and/or focal radiation reported greater cognitive impairment than other CNS treatment groups. Results show a significant association between brain metastasis patients’ subjective cognitive concerns and QOL, and an effect of CNS treatment on patient-reported cognitive outcomes. These data may be used to develop supportive care initiatives for brain metastasis patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.008 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.010 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".