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American Ginseng From Five Different Sources Has Differential Effects On Postprandial Blood Glucose

2006· article· en· W27683950 on OpenAlexaffabout
Elena Jovanovski, Anamaria Dascalu, Alexandra L. Jenkins, John L. Sievenpiper, Vladimir Vuksan

Bibliographic record

VenueThe FASEB Journal · 2006
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGinseng Biological Effects and Applications
Canadian institutionsSt. Michael's Hospital
Fundersnot available
KeywordsGinsengPostprandialAmerican ginsengMedicineDiabetes mellitusArea under the curveTraditional medicineAnimal scienceInternal medicineBiologyEndocrinology

Abstract

fetched live from OpenAlex

We have previously demonstrated that, among 8 popular ginseng species, cultivated American ginseng (Panax quinquefolius) is one of the most efficacious in lowering postprandial blood glucose. It is not known, however, whether any other batch of cultivated American ginseng would replicate this finding. The present study aimed to assess the glycemia lowering effect of American ginseng from five Ontario farms with varying growing conditions in a controlled multiple cross‐over intervention. 12 healthy individuals (5M:7F, age: 27± 2y, BMI: 24 ± 1 kg/m2) were tested on 6 separate occasions, after a 12h overnight fast. Each subject received 9g of American ginseng root from different farms, in random order, or a water control 40 min prior to a 75g oral glucose tolerance test. Venous blood samples were drawn prior to treatment intake and the 75 g glucose load and 15, 30, 45, 60, 90, 120 min after the glucose intake. Comparisons with control showed that ginseng from three farms significantly lowered blood glucose and area under the curve, farm A being the source of the most potent ginseng identified in this study. Overall, American ginseng reduces postprandial glycemia. However different batches do not consistently reproduce the identified glycemia lowering effect. Even among efficacious batches, differential glucose‐lowering amplitudes are observed. These variable biologic responses might be explained through compositional differences due to various growing conditions of ginseng. This calls for further identification of the active glycemia‐lowering components and subsequent ingredient‐based standardization of ginseng.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.067
Threshold uncertainty score0.482

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.214
Teacher spread0.207 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2006
Admission routes2
Has abstractyes

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