Bibliographic record
Abstract
Multicomponent coupling reactions have become of growing importance in the design of efficient synthetic methods. This chapter highlights some of the important general classes of the metal-catalyzed multicomponent reactions, with a focus upon those that use building blocks that are all, or nearly all, readily available, and therefore of potential industrial relevance. A common approach to metal-catalyzed multicomponent reactions involves exploiting carbonylation chemistry. The incorporation of carbon monoxide into products often involves a multicomponent reaction, where the carbonyl unit in the product is linked to two separate fragments. Transition metal-catalyzed multicomponent reactions have been employed to build up products that are themselves intermediates in subsequent, non-metal based reactions. While examples of these reactions are described above, one general manifold involves generating substrates for cycloaddition reactions, such as 1,3-dipoles for use in dipolar cycloaddition reactions. The transition metal catalyzed formation of 1,3-dipoles has been applied to multicomponent syntheses in a number of directions.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.010 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".