Oxidative stress does not influence local sweat rate during high‐intensity exercise
Bibliographic record
Abstract
New Findings What is the central question of this study? We evaluated whether oxidative stress attenuates the contribution of nitric oxide to sweating during high‐intensity exercise. What is the main finding and its importance? In contrast to our previous report of an oxidative stress‐mediated reduction in nitric oxide‐dependent cutaneous vasodilatation in this cohort during intense exercise, we demonstrated no influence of local ascorbate administration on the sweating response during moderate‐ (∼51% peak oxygen uptake) or high‐intensity exercise (∼72% peak oxygen uptake). These new findings provide important mechanistic insight into how exercise‐induced oxidative stress impacts sudomotor activity. Nitric oxide (NO)‐dependent sweating is diminished during high‐ but not moderate‐intensity exercise. We evaluated whether this impairment stems from increased oxidative stress during high‐intensity exercise. On two separate days, 11 young (24 ± 4 years) men cycled in the heat (35°C) at a moderate [500 W; 52 ± 6% peak oxygen uptake ( )] or high (700 W; 71 ± 5% ) rate of metabolic heat production. Each session included two 30 min exercise bouts separated by a 20 min recovery period. Local sweat rate was monitored at four forearm skin sites continuously perfused via intradermal microdialysis with the following: (i) lactated Ringer solution (Control); (ii) 10 m m ascorbate (Ascorbate; non‐selective antioxidant); (iii) 10 m m N G ‐nitro‐ l ‐arginine methyl ester ( l ‐NAME; NO synthase inhibitor); or (iv) 10 m m ascorbate plus 10 m m l ‐NAME (Ascorbate + l ‐NAME). During moderate exercise, sweat rate was attenuated at the l ‐NAME and Ascorbate + l ‐NAME sites (both ∼1.0 mg min −1 cm −2 ; all P < 0.05) but not at the Ascorbate site (∼1.1 mg min −1 cm −2 ; both P ≥ 0.28) in comparison to the Control site (∼1.1 mg min −1 cm −2 ). However, no differences were observed between treatment sites (∼1.4 mg min −1 cm −2 ; P = 0.75) during high‐intensity exercise. We conclude that diminished NO‐dependent sweating during intense exercise occurs independent of oxidative stress.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".