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Record W2772067948 · doi:10.1038/nrd.2017.221

Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome

2017· review· en· W2772067948 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueNature Reviews Drug Discovery · 2017
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetics and Neurodevelopmental Disorders
Canadian institutionsUniversité de MontréalCentre Hospitalier Universitaire Sainte-JustineMcGill University
FundersNIH Clinical CenterNational Institute of Neurological Disorders and StrokeNational Institute of Mental HealthIntellectual and Developmental Disabilities Research CenterHealth Resources and Services AdministrationFRAXA Research FoundationHospices Civils de LyonInstitut National de la Santé et de la Recherche MédicaleEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentU.S. Department of DefenseEuropean CommissionEuropean Federation of Pharmaceutical Industries and AssociationsAutism SpeaksSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungNational Institutes of HealthOdense UniversitetshospitalNational Science Foundation
KeywordsFragile X syndromeAutismNeurodevelopmental disorderClinical trialDrug developmentIntellectual disabilityMedicineAutism spectrum disorderNeuroscienceMetabotropic glutamate receptor 5Rett syndromeMetabotropic glutamate receptorPsychiatryPsychologyDrugAgonistBiology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesMeta-epidemiology (narrow)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.966
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0020.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.063
GPT teacher head0.354
Teacher spread0.291 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it