4.8 ARTERIAL STIFFNESS AND ITS RELATIONSHIP TO MORTALITY IN PATIENTS WITH PERIPHERAL ARTERY DISEASE
Bibliographic record
Abstract
Several studies (1,2) suggest that patients with peripheral artery disease (PAD) show an increase in arterial stiffness, nevertheless the impact on mortality is less documented. (3) 228 PAD patients mean age (68 ± 9 years) were followed-up for 4,8 ± 2 years. Anthropometric and clinical measurements were collected, ankle-brachial index (ABI) was estimated with standard protocol and hemodynamic parameters (central blood pressure, aortic pulse wave velocity [aPWV], augmentation index [Aix]) were measured using applanation tonometry. Prognostic factors of mortality were identified by Cox proportional hazards regression model. During follow-up 26 (11,6%) deaths occurred. Among them, 5 (19%) were of cardiovascular origin. The Cox analysis applied to data relative to the third tertile of aPWV (11.4–21.4, m/s), is significant for age, (p = 0.039), smoking history (p = 0.0003) non use of lipid lowering drugs (p = 0.026) and lower height (p = 0.007) but not for aPWV (p = 0.312), Aix (p = 0.075) and ABI (p = 0.305). The present study provides further insights into the lack of association between large artery stiffness, pressure wave reflections and mortality in PAD patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".