Patient self-assessed HBI correlates highly with physician-assessed HBI in the SECURE registry.
Bibliographic record
Abstract
The SECURE Registry compares the long-term safety of Crohn's disease (CD) patients treated with certolizumab pegol (CZP) with a non-CZP-treated control population. Patient- and physician-derived modified Harvey-Bradshaw Index (HBI) scores were compared in these patients, providing an analysis that has not previously been investigated. SECURE (NCT00844285) is a long-term observational study in the United States that will assess 2000 CZP-treated CD patients and 2000 CD patients treated with steroids, immunosuppressives, or other biologic agents for up to 10 years. Gastroenterologists and internal medicine physicians from communitybased and academic practice settings will follow patients using regular clinic visits and direct patient follow-up (Web/mail surveys and telephone calls). Medications will be prescribed according to usual patient/physician judgment. To assess the potential value of the HBI as a patient-reported outcome, we compared baseline physician-derived HBI scores and modified patient HBI scores (omitting the abdominal mass item). As of March 1, 2010, 819 patients had been recruited, 270 into the CZP cohort (median age, 40.0 years [range, 15-81]; 62% female) and 549 into the comparison cohort (median age, 42 years [range, 9- 88]; 58% female). At baseline, 41%, 40%, and 10% of patients in the CZP cohort had mild to moderate, moderate to severe, and severe disease activity, respectively, and 9% were in remission. In the non-CZP cohort, 42%, 17%, and 3% of patients had mild to moderate, moderate to severe, and severe disease activity, respectively, and 38% were in remission. Fifty-six percent of patients in the CZP cohort and 65% of patients in the non-CZP cohort had disease duration of greater than or equal to 5 years; 61% and 65%, respectively, had previously used biologic agents as therapy. Interestingly, based on 781 patients with paired assessments, the baseline physician and modified patient HBI scores were highly correlated (regression coefficient r=0.990 [95 %CI, 0.968-1.000], R2=0.908, p<0.0001).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.015 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".