To: A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer’s disease
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.291 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Recently, Yoshida et al. 1 reported a patient who developed fulminant liver failure, requiring urgent liver transplantation, 7 weeks after commencing interferon -1a (Rebif, Serono-Canada, Oakville, Ontario, Canada). The patient received a liver transplant in September 2000 and the authors have received new information that she had been started on nefazodone (Serzone, Bristol-Myers Squibb Canada, Montreal, Quebec) in February of 2000. Nefazodone has recently been reported in association with acute liver failure. The manufacturer of nefazodone has reported 23 cases of liver failure and 109 cases of hepatic adverse events out of 8.3 million users of this drug worldwide. The patient's liver enzymes were stable prior to starting interferon -1a and two-thirds of nefazodone-associated liver failure occurred within 4 months. Interferon -1a appears to be temporally implicated in the patient's liver failure but the authors cannot exclude the possibility that nefazodone may have been a factor or cofactor. The authors regret that they were unaware of this patient's nefazodone use until their paper appeared in print.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Neurology
- Topic
- Dementia and Cognitive Impairment Research
- Field
- Medicine
- Canadian institutions
- —
- Funders
- —
- Keywords
- DonepezilMedicineRandomized controlled trialDouble blindDiseaseAlzheimer's diseaseInternal medicinePediatricsDementiaPathologyAlternative medicine
- Has abstract in OpenAlex
- yes