Cognitive Planning Neural Correlates in a Pediatric Monozygotic Twin Pair Discordant for Obsessive-Compulsive Disorder
Bibliographic record
Abstract
Article AbstractBecause this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.To the Editor: Pediatric obsessive-compulsive disorder (OCD) is a debilitating illness characterized by intrusive thoughts and repetitive behaviors. Patients may exhibit poorer executive function, such as cognitive planning. Substantial overlap exists between brain areas implicated in OCD pathology and those involved in planning (eg, dorsolateral prefrontal cortex, posterior parietal cortex, extrastriate visual cortex, anterior cingulate cortex, inferior frontal gyrus), and functional magnetic resonance imaging (MRI) demonstrates that participants with OCD perform poorly and show less regional brain responsivity as task load increases in comparison to healthy controls. This robust finding could be useful in the domain of precision medicine, as it normalizes after cognitive-behavioral therapy and may be useful in individual activation profiles that could predict treatment response.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.002 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.003 | 0.000 |
| Research integrity | 0.001 | 0.011 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".