Retraction: Mitigation of azathioprine-induced testicular atrophy by taurine; an impact on inflammation, oxidative perturbations and apoptosis
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No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Post-publication record
OpenAlex flags this work as retracted, but it carries no matching Retraction Watch record in this frame.
Abstract
Azathioprine (AZA) is an effective anticancer drug, but some cases of testicular toxicity have been reported. The aim of this work was to investigate the protective effects of taurine (TAU), a reported antioxidant and antiinflammtory peptide, against AZA-induced testicular dysfunction in male rats and ascertain the contributing mechanisms. Forty adult male rats were allocated into four equal groups; (i) normal control rats, (ii) TAU group (100 mg/kg b.w/ day for ten weeks, (iii) AZA group (10 mg/day for four weeks); (iv) TAU/AZA group. As expected, AZA caused increased DNA damage in the testes, and alterations in sex hormones and sperm quality, including sperm count, viability, and motility. Moreover, testicular tissue from the AZA-treated group had increased levels of oxidative stress indicators, MDA, and reduced glutathione (GSH) levels, and decreased activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). These deleterious events were accompanied by upregulated levels of the ...
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Canadian Journal of Physiology and Pharmacology
- Topic
- Aldose Reductase and Taurine
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- —
- Keywords
- Oxidative stressSuperoxide dismutaseEndocrinologyGlutathioneInternal medicineAntioxidantCatalaseTesticular atrophySpermAndrologyBiologyMedicineEnzymeBiochemistry
- Has abstract in OpenAlex
- yes