Structural analysis of the peptidyl prolyl <i>cis</i>,<i>trans</i>-isomerase HP0175 from <i>Helicobacter pylori</i>
Bibliographic record
Abstract
Infections caused by the gram-negative bacterium Helicobacter pylori are associated with several pathways that include epidermal growth factor receptor (EGFR) and production of vascular endothelial growth factor receptor (VEGF).Of the several proteins secreted by H. pylori, HP0175 a peptidyl prolyl cis-, trans-isomerase (PPIase) has been linked to bind to toll-like receptors (TLR) allowing for the transactivation of EGFR and VEGF.TLRs are major players in innate immunity through their ability to recognize pathogens such as bacteria, fungi or viruses.HP0175 also causes cell damage, apoptosis and inflammatory responses.The following protein was initially crystallized as a homodimer (PDB ID:5EZ1), complexed with its inhibitor indole-2-carboxylic acid (I2CA) at 2.4 Å resolution.Here, we examine apo-HP0175 as a monomer with structure resolution of 2.34 Å. Apo-HP0175 crystallizes in space group p3121, with unit cell dimensions a=b=91.5 Å, c=67.7 Å with one molecule in the asymmetric unit.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".