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Record W2778546216 · doi:10.3732/apps.1700079

Using Herbarium‐Derived DNAs to Assemble a Large‐Scale DNA Barcode Library for the Vascular Plants of Canada

2017· article· en· W2778546216 on OpenAlexafffundabout
Maria Kuzmina, Thomas Braukmann, Aron J. Fazekas, Sean W. Graham, Stephanie deWaard, Anuar Rodrigues, B. A. Bennett, Timothy A. Dickinson, Jeffery M. Saarela, Paul M. Catling, Steven G. Newmaster, Diana M. Percy, Erin Fenneman, Aurélien Lauron‐Moreau, Bruce A. Ford, Lynn J. Gillespie, Subramanyam Ragupathy, Jeannette Whitton, Linda Jennings, Deborah A. Metsger, Connor P Warne, Allison Brown, Elizabeth Sears, Jeremy R deWaard, Evgeny Zakharov, Paul D. N. Hebert

Bibliographic record

VenueApplications in Plant Sciences · 2017
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic diversity and population structure
Canadian institutionsUniversité de MontréalCanadian Museum of NatureRoyal Ontario MuseumUniversity of ManitobaCanada Research ChairsYukon UniversityUniversity of New BrunswickUniversity of TorontoAgriculture and Agri-Food CanadaUniversity of British ColumbiaUniversity of Guelph
FundersGovernment of Canada
KeywordsBiologyBarcodeDNA barcodingHerbariumBiomeDNA sequencingGenetic genealogyEvolutionary biologyBotanyEcologyGeneticsDNA

Abstract

fetched live from OpenAlex

Premise of the study: Constructing complete, accurate plant DNA barcode reference libraries can be logistically challenging for large‐scale floras. Here we demonstrate the promise and challenges of using herbarium collections for building a DNA barcode reference library for the vascular plant flora of Canada. Methods: Our study examined 20,816 specimens representing 5076 of 5190 vascular plant species in Canada (98%). For 98% of the specimens, at least one of the DNA barcode regions was recovered from the plastid loci rbcL and matK and from the nuclear ITS2 region. We used beta regression to quantify the effects of age, type of preservation, and taxonomic affiliation (family) on DNA sequence recovery. Results: Specimen age and method of preservation had significant effects on sequence recovery for all markers, but influenced some families more (e.g., Boraginaceae) than others (e.g., Asteraceae). Discussion: Our DNA barcode library represents an unparalleled resource for metagenomic and ecological genetic research working on temperate and arctic biomes. An observed decline in sequence recovery with specimen age may be associated with poor primer matches, intragenomic variation (for ITS2), or inhibitory secondary compounds in some taxa.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.302
Threshold uncertainty score0.608

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.004
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0040.005
Science and technology studies0.0030.001
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.034
GPT teacher head0.274
Teacher spread0.241 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations99
Published2017
Admission routes3
Has abstractyes

Explore more

Same venueApplications in Plant SciencesSame topicGenetic diversity and population structureFrench-language works237,207