Bibliographic record
Abstract
White matter hyperintensities (WMH) are regions of increased pixel intensity in T2-weighted MRI which are correlated with several neurodegenerative diseases. Human segmentation of WMH is time consuming and inconsistent, motivating automation of WMH segmentation. While many algorithms for this task have previously been proposed, few have been validated on MRI from different sources, despite the sensitivity of most algorithms to source-specific image features. This thesis presents a segmentation algorithm called “Voxel-Wise Logistic Regression” (VLR), which provides both good interpretability and segmentation performance. VLR uses FLAIR MRI to estimate the WMH class probability image using spatially varying logistic parameters β(x). These “parameter images” also concisely summarize the model class discrimination. Additionally, a validation framework called “Leave-One-Source-Out Cross Validation” (LOSO-CV) is introduced, which provides more realistic estimation of model performance on “never-before-seen” MRI sources. Segmentation performance of the VLR model under LOSO-CV is presented using 96 open-source images from 7 MRI sources.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".