Novel Mycoplasma Agalactiae with new P30 Protein Pattern by Major Change in 17 Amino Acids
Bibliographic record
Abstract
M. agalactiae (Mycoplasma agalactiae) is the main agent of CA (contagious agalactia) that is primarily disease of dairy sheep and goats. In Iran, a three-valent Agalactia inactivated vaccine were prepared based on three M. agalactiae isolated from milk secretion of sheep and goat of Taleghan, Shiraz and Lorestan and preventive policies against CA disease founded in Razi Institute since 1966. The P30 is a specific and stable lipoprotein of M. agalactiae. In this study, complete coding sequence of P30 gene of three Iranian vaccine strains and ten recently field isolates were analyzed in nucleotide and protein levels by bioinformatics tools. Interestingly, results observed a novel protein pattern K106VLKTKEIRLSQERKLS122 in P30 protein of vaccine strains compared to field isolates and the other available sequences in GenBank. Our findings demonstrated different B and T cell epitope patterns in Iranian vaccine strains. We suggested that the major change in P30 protein pattern may be occurred due to mutation during adaptation process in PPLO (Pleuropneumonia-Like Organisms) broth media.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".