Cytokeratin 7 negative and cytokeratin 20 positive orbital metastatic breast carcinoma
Bibliographic record
Abstract
Metastatic tumours to the orbit account for only a small proportions of orbital mass lesions and typically come from breast, prostate, lungs or metastatic melanomas . Identifying the source of the primary tumour may represent a challenge, as they are sometimes undiagnosed or the malignancies may sometimes have a different microscopic morphology. In metastatic carcinomas originating from the breast, Cytokeratins and mammary gland specific antibodies are generally informative, showing a classic CK7 +, CK20 −, Mammaglobin +, GCDFP-15 + profile. Herein, we present a case of breast metastatic tumour to the orbit with an unusual and extremely rare histochemical profile being negative for CK7 and positive for CK20. Our findings highlight the higher sensitivity and specificity of the novel GATA-3 compared with the classic breast immunohistochemical (IHC) markers and advising for careful interpretation of current IHC panels.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".