Database of resistance related metabolites in Wheat Fusarium head blight Disease (MWFD)
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Fungal diseases are an increasing threat to worldwide food security. Fusarium head blight (FHB), primarily caused by Fusarium graminearum, is a devastating disease of Triticum aestivum (bread wheat). Partial resistance to FHB of several wheat and barley cultivars includes specific metabolic responses to inoculation. Investigation of metabolic changes in plants, following pathogen infection, provides valuable data for understanding of the role of metabolites and metabolism in plant-pathogen interaction and resistance. Determination of functions of metabolites in resistance can also inspire the development of antifungals. Metabolic changes induced by FHB in resistant and susceptible plants have been previously investigated. However, the functionality of the majority of these investigated metabolites remains unknown. The 'Metabolites in the Wheat Fusarium head blight Disease' (MWFD) database was compiled in order to determine possible targets and roles of these molecules in resistance to FBH and aid in the development of related synthetic antifungals. The MWFD database allows for the quick retrieval of known resistance related metabolites, associated target proteins and their sequence analogues in wheat and Fusarium genomes. The database can be searched for compounds, MeSH terms, as well as protein targets. This comprehensive, manually curated, collection of resistance related metabolites is available at https://bioinfo.nrc.ca/mwfd/ index.php.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it