Bibliographic record
Abstract
Multiple sclerosis (MS) typically presents in young adulthood, often at a time when decisions about reproduction have not been made yet. Although some individuals with MS will choose not to have children for MS-related reasons,1 many others will choose to do so. For women, this raises particular concerns. Women with MS are slightly more likely to deliver infants who are small for gestational age, but maternal MS is not associated with a greater risk of birth defects.2 During the third trimester of pregnancy, annualized relapse rates decrease, followed by an increased relapse risk particularly in the first 3 months of the postpartum period.3 Consistent with this observation, new, enlarging, or gadolinium-enhancing lesions are often detected postpartum.4 Disease activity gradually returns to prepartum levels, and no long-term adverse effects of pregnancy on disease progression have been identified.5 In the modern therapeutic era, women with MS and their physicians face sometimes challenging decisions regarding disease-modifying therapy (DMT) and how this will affect maternal and fetal health. Although use of injectable DMTs prepartum does not appear to alter the aforementioned pattern of disease activity in the third trimester or postpartum,6 this may not be the case for more effective therapies, such as natalizumab, which are associated with rebound disease activity when they are withdrawn.7
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".