Chemoreflex function and brain blood flow during upright posture in men and women
Bibliographic record
Abstract
Orthostatic intolerance is more common in women than men, and some studies have found that women in the early follicular (EF) phase of the menstrual cycle experience the greatest feelings of lightheadedness. Chemoreflex function while supine or upright was investigated to determine the potential contribution of ventilatory control to these phenomena. Men (n = 13) and women (n = 14) were tested while supine and 70° upright (head-up tilt [HUT]) and given: (1) normoxia or (2) hypercapnia (5% CO2). Women were tested during the EF phase (days 2–5) and the midluteal phase (ML; days 18–24). During HUT, all groups reduced cerebrovascular resistance index (men: 1.45 ± 0.08 to 1.42 ± 0.07 mmHg/(cm·sec), EF: 1.38 ± 0.11 to 1.26 ± 0.10 mmHg/(cm·sec), ML: 1.25 ± 0.07 to 1.09 ± 0.07 mmHg/(cm·sec); P ≤ 0.019); however, only men increased ventilation (men: 11.99 ± 0.65 to 13.24 ± 0.83 L/min; P < 0.01). In response to hypercapnia in the supine position, men had a smaller increase of diastolic middle cerebral artery velocity compared to women in the ML phase (men: +9.1 ± 2.0 cm/sec, ML: +15.7 ± 3.1 cm/sec, P = 0.039). During hypercapnia in HUT (compared to hypercapnia while supine), all groups had an augmented increase of ventilation (men: +7.46 ± 1.34 vs. +5.84 ± 1.09 L/min, EF: +6.71 ± 0.83 vs. +5.48 ± 0.66 L/min, ML: +7.99 ± 1.13 vs. +5.65 ± 0.81 L/min; P ≤ 0.028), suggesting that all groups experienced augmentation of the CO2 chemoreflex; however, only men had an augmented increase of mean arterial pressure (+0.10 ± 0.58 to +4.71 ± 0.87 mmHg; P ≤ 0.017). Our results indicate that men have different ventilatory responses to upright tilt compared to women, and that the CO2 chemoreflex response is enhanced in upright posture in both sexes. Furthermore, sexually dimorphic blood pressure responses to this chemoreflex enhancement are evident.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".