1649: Spectict Capromab Pendetide Independently Predicts BDFS in Long Term Outcome Study
Bibliographic record
Abstract
INTRODUCTION AND OBJECTIVE: To evaluate SPECT/CT Capromab pendetide as a lymph node staging tool for the prediction of biochemical disease free survival (bDFS) in patients prior to definitive radiation therapy for prostate cancer.METHODS: 239 patients with clinical T1c-T3b NxMO prostate cancer were evaluated for lymph node status using co-registered SPECT/CT Capromab pendetide (SPECT/CT) image sets prior to undergoing primary image guided radiation therapy (IGRT) seed implant (SI).Median follow-up was 47.2 months (range 24.8-96.1 ).Patients identified with local vs.distant disease by SPECT/CT were followed for bDFS post-definitive radiation therapy using either Sl-alone, or external beam radiation plus Slboost (EBRT +SI).Patients with distant SPECT/CT findings were assumed to represent possible false positive findings, when not confirmed by secondary assessment.At the clinical discretion of the Urologist, a total of 65 patients underwent node sampling and 50 received neoadjuvant hormone therapy.Biochemical disease free survival (bDFS) was calculated using 3 failure criteria: ASTRO consensus (ASTRO) definition, PSA ~ 1.0 ng/ml and PSA ~ 0.5 ng/ml after nadir.RESULTS: In univariate Cox regression analysis, SPECT/CT distant findings were found to be statistically significant predictors of bDFS in both the entire cohort and in the hormonal na"ive sub-population.For the entire cohort, 217 patients with local and 22 with extraperiprostatic disease by SPECT/CT evaluation had a 7-year bDFS of 90.6% and 66.1% (p = 0.0003); 87.1% and 45.5% (p < 0.0001); 85.8% and 43.8% (p < 0.0001), by the 3 criteria: ASTRO, PSA ~ 1.0 ng/ml, and PSA ~ 0.5 ng/ml after nadir, respectively.For hormonal na"ive patients, the local (n=171) and distant (n =18) subsets, 7-year bDFS rates were 91.6% and 64.2% (p = 0.0004); 88.4% and 31.0%(p = 0.0001); 86.7% and 30.0%(p < 0.0001) by the 3 criteria, respectively.On multivariate Cox regression analysis, SPECT/CT findings significantly predicted for bDFS.The hazard ratio for patients with distant disease by SPECT/CT was found to be 3-fold greater (p = 0.020) for the entire cohort, and 4-fold greater (p = 0.015) for the hormonal na"lve sub-population; with respect to bDFS failure using ASTRO criteria, when compared to those with local disease, after controlling for all confounding factors.CONCLUSIONS: SPECT/CT Capromab pendetide was found beneficial for patient selection prior to local therapy by independently predicting bDFS.SPECT/CT may predict for the benefit of long-term hormonal therapy for patients with distant findings.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".