P287 Clinical course of Crohn’s disease followed up in a period of six years in one reference centre
Bibliographic record
Abstract
Many studies have shown that the late diagnosis is related to the development of complications and poor prognosis for Crohn’s disease (CD). The aim of our study is to perform a retrospective analysis of the clinical course of CD in patients hospitalised in one reference clinical centre for a period of 6 years. For a period of 6 years (2011–2017), the 140 patients were divided into two groups: group I - 108 (77.10%) diagnosed with CD within one year of the onset of complaints and group II - 29 (20.70%) who were diagnosed within 24 months of the onset of complaints. There was a follow-up of the clinical course of the disease, the occurrences of extra-intestinal manifestations, intestinal complications and the therapy performed. There is no significant difference between the two study groups in terms of CD activity (assessed via the CDAI), the Montreal classification, the received treatment and the intestinal complications. A significant difference was found with respect to the average number of hospitalisations (4 for group I and 6 for group II, p <0.05), the EIM frequency (group II prevalence - 95.8%), the course of the disease and perianal disease. In group I 35% of patients with colon localisation (L2) on debut progressed in the first year to ileocolonic (L3). In the first year, perianal disease (p) increased to 22% and in the sixth year it reached 70%. The penetrating and stricturing form of the disease (B2 and B3) reached 21% in the first year, while in the sixth year it was already 60.7% (Table 1). Course of CD according to the Montreal classification of patients in group I and II in debut at years 1, 3 and 6. In group II there was a constant trend of increase of the perianal disease, which grew almost 7 times in the third year from 9.1% to 63.40%, and this tendency is maintained during the sixth year (61.9%). Regardless of the time of diagnosis, about half the patients had a debut with a surgical intervention (58.1% for group I and 50.0% for group II), with about one third of the subjects undergoing surgery during the course of the disease (32.6% for group I and 35.7% for group II). Regardless of the equally applied treatment in late-diagnosed patients, an increased number of hospitalisations, extra-intestinal manifestations, increasing progression in the occurrence of perianal disease, and a penetrating and stricturing form of CD are being observed.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".