A131 HOW EFFECTIVE IS COLONOSCOPIC BALLOON DILATION IN ANASTOMOTIC AND NON-ANASTOMOTIC STRICTURES OF CROHN’S DISEASE?
Bibliographic record
Abstract
Stricture formation is a common and challenging complication of Crohn’s disease (CD) with a significant impact on disease management. Treatment options include medical therapy, surgical resection or strictureplasty. Another less invasive approach is colonoscopic balloon dilation (CBD). To assess the efficacy and safety of CBD in our cohort of Crohn’s disease patients with strictures. From January 2006 to March 2016, we conducted a retrospective chart review of CD patients in our practice who underwent CBD. The primary outcomes were technical and clinical success of CBD. Technical success was defined as subjective improvement in the stricture and the ability to pass the scope through it post-dilation. Clinical success was defined as subjective clinical improvement at follow up visits. Secondary outcomes included post-CBD complication rate, surgery-free survival and repeat CBD-free survival. A total of 123 patients with 152 strictures were included in the analysis. The mean age of the sample patients was 48.5 years (range 20–86). 63.2% of patients were females. Anastomotic strictures were the cause in (52.6%). Medications used at the time of CBD include biologic therapy in 30.3%, immunomodulators (azathioprine, methotrexate and 6-mercaptopurine) in 30,9%, steroids in 27.6% and 5-ASA derivatives in 7.2%. The median dilation diameter was 15 mm. 73% of the procedures had technical success while 88.8% had clinical success. CBD of primary strictures was more likely to achieve technical success (80.6% vs. 66.3%; p=0.047) but not clinical success (90.3% vs. 87.5%; p=0.59). Two patients experienced post-CBD bleeding (requiring hospitalization and blood transfusion) while another two patients experienced self-limited pain. Dilated secondary strictures were more likely to undergo a repeat-CBD (38.8% vs. 31.9%; p=0.38) and post-CBD surgery (28.8% vs. 25%; p=0.6) when compared to primary strictures. Overall, CBD is an effective treatment option for CD strictures with more success in primary strictures. Serious complications were encountered, although not insignificant, at a low rate. None
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".