Inhibition of the Fibrinogen‐Like Protein 2:Fc<i>γ</i><scp>RIIB</scp>/<scp>RIII</scp> immunosuppressive pathway enhances antiviral T‐cell and B‐cell responses leading to clearance of lymphocytic choriomeningitis virus clone 13
Bibliographic record
Abstract
Summary Persistent viruses evade immune detection by interfering with virus‐specific innate and adaptive antiviral immune responses. Fibrinogen‐like protein‐2 ( FGL 2) is a potent effector molecule of CD 4 + CD 25 + FoxP3 + regulatory T cells and exerts its immunosuppressive activity following ligation to its cognate receptor, Fc γ RIIB / RIII . The role of FGL 2 in the pathogenesis of chronic viral infection caused by lymphocytic choriomeningitis virus clone‐13 ( LCMV cl‐13) was assessed in this study. Chronically infected fgl2 +/+ mice had increased plasma levels of FGL 2, with reduced expression of the maturation markers, CD 80, CD 86 and MHC ‐ II on macrophages and dendritic cells and impaired production of neutralizing antibody. In contrast, fgl2 −/− mice or fgl2 +/+ mice that had been pre‐treated with antibodies to FGL 2 and Fc γ RIIB / RIII and then infected with LCMV cl‐13 developed a robust CD 4 + and CD 8 + antiviral T‐cell response, produced high titred neutralizing antibody to LCMV and cleared LCMV . Treatment of mice with established chronic infection with antibodies to FGL 2 and Fc γ RIIB / RIII was shown to rescue the number and functionality of virus‐specific CD 4 + and CD 8 + T cells with reduced total and virus‐specific T‐cell expression of programmed cell death protein 1 leading to viral clearance. These results demonstrate an important role for FGL 2 in viral immune evasion and provide a rationale to target FGL 2 to treat patients with chronic viral infection.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".