A238 A COMPARATIVE ANALSYS OF FIBROSIS BY TRANSIENT ELASTOGRAPHY AND LIVER BIOPSY IN PATIENTS WITH BIOPSY PROVEN NASH.
Bibliographic record
Abstract
According to the Canadian Liver Foundation, the death rate from liver disease has risen to nearly 30 percent. Fatty liver disease (FLD) more specifically has been highlighted to affect nearly 30 percent of the Canadian population, with Non-alcoholic steatohepatitis (NASH); a sub-type of FLD, causing a 50 percent increase in mortality secondary to cirrhosis & its complications. This value equates to greater number of hospitalizations, emergency room admissions, & more frequent visits to general practitioners and specialists. As liver biopsy remains the gold-standard for the diagnosis of NASH, & transient elastography a non-invasive tool in the assessment & monitoring of liver disease. Our aim was to study how the NASH activity Score (NAS), & its components (Steatosis, Ballooning, & Fibrosis) correlated to Liver Stiffness (LS) by fibroscan. 67 patients who had undergone a Liver Biopsy for confirmative diagnosis of NASH and staging of fibrosis. All Liver biopsies with were conducted at one facility and interpreted by a liver pathologist. Fibroscan tests were conducted at a separate facility and liver stiffness was measured in kilopascals. Data was collected and retrospectively analysed for: Liver stiffness (LS), and various aspects of the Pathology report. Only patients with NAS≥2 (NASH Activity Score) were included in the study. Of the 67 included in our cohort, 41 were males, & 26 females. Mean age for males was 48.39, and females 52.46. 65 patients underwent both a fibroscan and biopsy with a mean time of 161.46 days in between the two tests. Fibroscan: LS to NAS showed a strong correlation with a P-value of 0.021. (Figure1) Mean LS was 11.60kPa, with 11.60kPa, and 11.30kPa for males and females, respectively. 58.2% of our cohort underwent serial fibroscans. Liver stiffness (kPa) values varied significantly when compared to Brunt fibrosis on Liver biopsy. No particular range of stiffness was identifiable to a specific stage of brunt fibrosis. (Table 1) When comparing LS to Ballooning, there was no significant correlation, with a linear regression model resulting in R2 value of 0.0007. While LS to Lobular Inflammation resulted in a R2 value of 0.0142. Although Liver stiffness by transient elastography shows a strong correlation to NAS; however, it does not prove to be correlated to any one individual component of the NAS score. We plan to further assess these findings in a larger cohort in the future. Table 1: Liver Fibrosis (Liver stifffness Vs. Brunt Fibrosis) None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".