A161 EVALUATING THE DIFFERENCES IN PERCEIVED STRESS AMONG NON-INFLAMMATORY AND INFLAMMATORY IBD FLARES
Bibliographic record
Abstract
The presence and severity of symptoms in IBD correlate poorly with the degree of inflammatory activity, especially in Crohn’s disease (CD). Psychological factors, including perceived stress and mood disruption are associated with symptom activity. This relationship is bidirectional with increased symptoms predicting later increased perceived stress and vice versa. It is unclear whether the association between high perceived stress and active symptoms is weighted more towards high perceived stress being associated with symptomatic activity in individuals and no concurrent active inflammation than it would be in persons with increased symptoms and evidence of intestinal inflammation. To evaluate whether perceived stress is associated with increased symptoms in non-inflammatory versus inflammatory IBD flares. We recruited 487 persons from the University of Manitoba IBD registry to assess the relationship between intestinal inflammation, symptomatic disease activity, and psychologic factors. Disease activity was assessed using the Harvey Bradshaw Index (HBI) for CD and the Powell Tuck Index (PTI) for UC. Perceived stress was measured using the Cohen Perceived Stress (CPSS) scale with high scores defined as ≥ 20. A fecal calprotectin (FCAL) level >250ug/g was the cut point for active inflammation. An inflammatory flare was defined as a FCAL > 250ug/g and disease index >4. A non-inflammatory flare was defined as FCAL ≤250 and disease activity index >4. Completed surveys and stool samples were submitted at baseline, 3 months and 6 months. For CD (n=265), 31 (11.7%) were in an inflammatory flare at baseline while 55 (20.8%) were in a non-inflammatory flare. For UC (n=222) 32 (14.4%) were in an inflammatory flare while 39 (17.6%) were in a non-inflammatory flare. There was no significant difference in the likelihood of having a high CPSS score between those with inflammatory vs non-inflammatory flares either at baseline or at 6 months(Table 1). There were no differences in the scores on individual items in the CPSS score between persons in inflammatory flares versus those in non-inflammatory flares. Increased perceived stress is equally associated with increased symptoms with persons with IBD regardless of the presence of inflammatory activity. Table 1. Clinical Scores None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".