10 The use of speckle tracking echocardiography to assess myocardial performance in monochorionic diamniotic twins with and without twin to twin transfusion syndrome
Bibliographic record
Abstract
<h3>Purpose</h3> Data on myocardial performance in monochorionic diamniotic (MCDA) twins during the early neonatal period is lacking. These infants are at risk of developing twin to twin transfusion syndrome (TTTS). We aimed to assess myocardial function using speckle tracking echocardiography (STE) in MCDA twins with and without TTTS. We hypothesise that infants exposed to TTTS would exhibit lower values for strain and strain rate measured using (STE) during the early neonatal period. <h3>Methods</h3> We performed a prospective observational study of 4 twin groups: Uncomplicated MCDA, MCDA twins with selective IUGR, MCDA with TTTS in receipt of SLPCV (MCDA and LASER) and MCDA twins with TTTS not receiving SLPCV (MCDA no LASER). Serial echocardiography was performed on day one, day two and between days 5–7 of life. Assessment of myocardial performance included the use of STE. <h3>Results</h3> Forty seven twin pairs were enrolled in the study: 21 uncomplicated MCDA; 14 selective IUGR; 6 TTTS no LASER, and 6 TTTS and LASER. Recipient TTTS no LASER infants had lower LV and RV strain (which persisted throughout the first week. Function measurements in the TTTS no LASER donor group were significantly higher than the recipient counterparts. <h3>Conclusion</h3> This is the first study using STE to highlight the poor myocardial performance in MCDA twins exposed to TTTS who do not undergo SLPCV. This highlights the need for close monitoring of their haemodynamic status during the early neonatal period. Further study is warranted to explore this condition further.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".