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Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

2018· article· en· 711 citations· W2791854743 on OpenAlex· 10.1038/s41593-018-0275-1

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Non-randomized trialObservationalBench or experimental
Classifier consensus
ObservationalBench or experimental
Teacher imitation scores

Codex

Observational0.869
Bench or experimental0.129
Not applicable0.006
Other design0.003
Metaresearch0.003
Research integrity0.002
Open science0.001
Case report0.001
Theoretical or conceptual0.001
Science and technology studies0.000
Scholarly communication0.000
Meta-epidemiology (broad)0.000
Bibliometrics0.000
Meta-epidemiology (narrow)0.000
Simulation or modelling0.000
Systematic review0.000
Randomized trial0.000
Qualitative0.000
Non-randomized trial0.000
Meta-analysis0.000

Gemma

Observational0.734
Bench or experimental0.043
Not applicable0.008
Theoretical or conceptual0.005
Open science0.002
Metaresearch0.001
Simulation or modelling0.001
Research integrity0.001
Non-randomized trial0.001
Case report0.001
Meta-epidemiology (broad)0.000
Science and technology studies0.000
Bibliometrics0.000
Meta-epidemiology (narrow)0.000
Randomized trial0.000
Meta-analysis0.000
Qualitative0.000
Scholarly communication0.000
Systematic review0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.010
GPT teacher head0.291
Teacher spread
0.281 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case-control and family-based studies were met…

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