Peptidergic mediation of response to stress: Focus on bombesin-like peptides.
Bibliographic record
Abstract
In addition to the relatively well established role of corticotropin-releasing hormone (CRH), and arginine-vasopressin (AVP) in the mediation of the stress response, there is reason to believe that the bombesin (BN) family of peptides may also contribute to the integration of these responses. Indeed, central administration of BN-like peptides produces endocrine, autonomic and behavioral effects, resembling those elicited by stressor exposure as well as by exogenously administered CRH and/or AVP. These observations led us to hypothesize that BN-like peptides may be important mediators of the stress response and that this family of peptides may mediate their stress-relevant effects via activation of CRH and/or AVP circuits. Using physiological approaches we demonstrated that stressor exposure is associated with changes in post-mortem tissue levels of BN-like peptides, BN-like peptide receptor densities and in the in vivo release of BN-like peptides from selected brain sites. Using pharmacological approaches we showed that (1) blockade of central CRH receptors with alphah-CRF attenuated BN-induced neuroendocrine and autonomic activation and (2) central BN administration elicited site-specific alterations in endogenous levels of CRH and AVP as well as the release of CRH and AVP from selected brain sites. Together, these data provide evidence for the involvement of BN-like peptides in the mediation and/or modulation of the stress response via activation of CRH and/or AVP neurons.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".