A322 NON-ALCOHOLIC FATTY LIVER DISEASE: DOES A CLINIC SPECIALIZED COUNSELLING ON NUTRITION AND EXERCISE REGIMEN HAS A CLINICAL IMPACT?
Bibliographic record
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a disease spectrum which includes benign simple steatosis (SS) and the more severe non-alcoholic steatohepatitis (NASH), affecting 20% to 30% of the general population in North America. It is linked to obesity and diabetes mellitus type II. Treatments options include healthy diet, physical activity and weight loss. To assess the clinical impact of a specialized nutrition clinic that provides counselling on nutrition and exercise regimen. This is a prospective cohort study. Patients data included here are patient demography, anthropometry (weight, BMI, waist circumference) and blood works (liver enzymes, HbA1c, glucose, lipid profile). Bloodwork and anthropometry were repeated at 6 months. Nutritional counseling and exercise regimen tailored to the patients were provided by a nutritionist and included oral supplements (Omega-3, Vitamin E, Vitamin D and Vitamin C). Significance of differences has been evaluated with Wilcoxon signed rank test for non-parametric data. Among 77 patients referred to the NAFLD clinic, 42 consented to the study. The median age was 49.5 years (IQR: 39, 56), with 53% females and 58% non-Hispanic white. 17 subjects were seen at 6 month-follow-up visit, 11 did not show and 14 are pending. For the 17 patients, baseline to 6 months measurements were: weight (mean 92.8 +/- 19.1 vs mean 90.7 +/- 19.0 kg); BMI (mean 33.3 +/- 6.0 vs mean 32.5 +/- 6.0 kg/m2); waist circumference (mean 107.8 +/- 13.0 vs mean 105.6 +/- 12.2 cm); AST (mean 45.8 +/- 31.5 vs mean 30.3 +/- 14.6 microU/L), ALT (mean 66.2 +/- 45.8 vs mean 45.2 +/- 30.5 microU/L). We observed a statistically significant difference for body weight (p-value <0.005), BMI (p-value <0.01) and AST (p-value <0.005). Of the 17 seen at 6 months, 3 lost ≥ 5% of their weight, representing 11% of those who came back at 6 months and those who were lost to follow-up. Six-months results suggest a favorable trend toward improvements in anthropometry and liver enzymes but there is a significant number of patients lost to follow-up. Therefore, it is too early to determine if a nutritional clinic dedicated to NAFLD has a significant clinical impact. None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.015 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".