P303 Serological assessment of type XVI collagen reflects intestinal strictures in Crohn’s disease patients
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Stricturing disease remains one of the biggest complications leading to intestinal resection in Crohn’s disease (CD), and affecting 30–50% of patients with CD. Intestinal strictures are caused by fibrosis development, as a result of increased collagen deposition. Intestinal fibroblasts and myofibroblasts are the main effector cells for intestinal fibrosis development and intestinal subepithelial myofibroblasts have shown to produce significantly elevated levels of type XVI collagen in CD patients. Thus, we investigated a novel serum biomarker, quantifying type XVI collagen (C16-C), as a biomarker for intestinal fibrosis in CD patients. Serum from CD patients (n = 44) and healthy subjects (n = 50) was included. The Montreal classification for CD disease behaviour (B1, non-stricturing/non-penetrating: n = 20; B2: stricturing, n = 11; B3: penetrating n = 13) and disease location (L1, ileum: n = 14; L2, colon: n = 5; L3, ileum + colon: n = 25) was applied. The patients were classified as having inactive disease (n = 20) or active disease (n = 24) based on the Crohn’s disease Activity Index (CDAI) score. Competitive ELISA was applied for the quantification of C16-C in serum from CD patients (total serum samples: n = 94). The biomarker C16-C was significantly elevated in patients with CD compared with healthy donors (p < 0.001, AUC: 0.81). CD patients with strictures (B2) demonstrated significantly elevated serum levels of C16-C compared with CD patient without strictures (B1 and B3), and healthy donors. Furthermore, the diagnostic accuracy to separate CD patients with strictures (B2) from CD patient without strictures (B1 and B3) was 76% (p < 0.01, AUC: 0.76) and healthy donors 96% (p < 0.001, AUC 0.82). In addition, C16-C was also elevated in CD patients with ileum or ileum+colon disease involvement compared with only colon involvement and healthy donors (p < 0.05). There was no significant difference between patients with active or inactive disease. Type XVI collagen measured in serum (C16-C) of CD patients and healthy donors. C16-C is significantly higher in Crohn’s disease patients with strictures. Our data demonstrate that type XVI collagen can be quantified in serum from CD patients. The biomarker C16-C was significantly associated with stricturing disease phenotype, indicating that this biomarker might be a biomarker for intestinal fibrosis in CD, and may predict intestinal fibrosis development in CD.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it