A262 QUALITY OF LIFE IN PRE-ADOLESCENT CHILDREN AFTER PEDIATRIC LIVER TRANSPLANT FOR BILIARY ATRESIA IS SIMILAR IN EUROPE AND CANADA
Bibliographic record
Abstract
Biliary atresia (BA) is the commonest indication for pediatric LT performed in infants, with excellent long-term patient and graft survival world-wide. Optimizing durable outcomes for this patient population can be enhanced by understanding health-related quality of life (HRQoL) concerns. This pilot study aimed to evaluate and compare HRQoL of middle-school aged BA subjects who underwent LT in Europe and Canada, and to explore the relationship between HRQoL with demographic and medical variables. Following available guidelines, the English-version of a pediatric liver transplant-specific HRQoL questionnaire (PeLTQL) available for children 8 to 18 years, was translated and cross-culturally adapted into five different languages. Inclusion criteria included BA subjects with current age between 8 to 12 years who underwent LT before the age of two years followed in one of 8 different pediatric LT centers in Canada or in a ChilSFree/EPLTN network program. Patients completed validated disease-specific (PeLTQL) and generic (PedsQL™) HRQoL tools. Their parents completed the corresponding, validated parent-proxy tools. Total PeLTQL and PedsQLTM scores range between 0 and 100, with higher scores indicating better HRQoL. Patient demographics and medical variables were also reviewed. A total of 64 [female 54%, white 83.4%, median age 9.77 (range 8.05–12) years] BA subjects 6 or more years after LT were evaluated. Polish, Spanish, Italian, English, German and French questionnaires were completed by 19, 18, 10, 10, 5 and 2 BA subjects respectively. High correlation was seen between patient-reported and parent-reported PeLTQL scores (r=.71, p <0.0001) and between PeLTQL and PedsQLTM scores (r=.61, p<0.0001). Total PedsQL and PeLTQL scores were not statistically different between different language-speaking populations. Higher total PeLTQL scores were seen in subjects on immunosuppression monotherapy (60.9%, 100% on Tacrolimus) compared to patients on dual or multiple therapy (n = 39 vs 23; PeLTQL Total Score 78.4 ± 12.9 vs 68.5 ± 18.5, p= 0.03). Total PedsQL and PeLTQL scores were not different in pediatric LT recipients with BA across six different language-speaking populations in this pilot study, suggesting similarity of broader determinants of health issues. Ongoing work is targeting better understanding of the impact of immunosuppression requirements on HRQoL. SETH (Liver Transplant Spanish Society)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".