A181 REAL-LIFE EFFICACY OF ELBASVIR/GRAZOPREVIR (EBV/GZV) FOR THE TREATMENT OF CHRONIC HCV GENOTYPE 1 AND 3 INFECTION
Bibliographic record
Abstract
The introduction of all-oral direct acting antiviral (DAA) regimens has allowed for better tolerated, shorter, and more effective courses of therapy for HCV infection. Elbasvir (EBV, NS5A inhibitor) and grazoprevir (GZV, NS3/4A protease inhibitor) is a new fixed dose combination that has demonstrated sustained virologic response (SVR) rates above 90% in a broad range of treatment-naïve and experienced populations, including people who inject drugs (PWID). We sought to evaluate the efficacy of EBV/GZV in a clinical setting serving HCV-infected PWID. An observational evaluation was conducted among HCV-infected patients seen at the Vancouver Infectious Diseases Centre (VIDC), where they had access to a multidisciplinary model of care to address medical, psychiatric, social and addiction-related needs prior to, during and after HCV therapy. All individuals that received EBV/GZV did so according to current clinical guidelines. At the time of the current analysis, the primary endpoint was defined as SVR-4, an undetectable HCV RNA four weeks post-treatment. Demographic and clinical correlates of success were also evaluated. To date, 13 individuals have received EBV/GZV in our program, 7 genotype 1a, 2 genotype 1b, and 4 genotype 3a (EBV/GZV administered in combination with sofosbuvir). Key demographic information includes: mean age 49.5 years, 23% female, 15% cirrhotic, 15% HIV co-infect and 85% current PWID. Adherence rates are high, with all patients having missed 0–2 doses. To date, six patients have reached the primary endpoint and 100% have achieved SVR-4, including 4/4 individuals with genotype 3a infection. Data will be presented on 20 patients with the SVR12 endpoint having been achieved. The combination of EBV/GZV (with or without sofosbuvir) appears highly effective in clinical practice in a population similar to that enrolled in the C-EDGE CO-STAR protocol. If these preliminary data are confirmed, EBV/GZV will become another highly potent therapeutic option available for the treatment of HCV infection in diverse populations, including PWID None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".