A41 PERIOD PREVALENCE ESTIMATE OF PRIMARY BILIARY CHOLANGITIS IN NOVA SCOTIA
Bibliographic record
Abstract
Primary Biliary Cholangitis (PBC) is a rare autoimmune cause if chronic liver disease. There exists an effective treatment for these patients, ursodeoxycholic acid (UDCA), but unfortunately 30–40% of patients do not have n adequate response or cannot tolerate it. New therapies are currently being researched. A recent Canadian Institute of Health Information report suggested that there are over 500 patients in the Maritime Provinces with PBC, which was much higher than expected. This warranted a review to assess Nova Scotia’s current prevalence of PBC as part of a quality assurance and resource planning initiative in our center. As part of a quality assurance initiative, we collected data from the Central Laboratory in Nova Scotia to determine how many patients in our province have PBC. The Central Laboratory database started being routinely used April 2009 and we used data until July of 2017. We considered a positive AMA and an elevated Alkaline Phosphatase to be considered having PBC. Period prevalence was calculated using the population of Nova Scotia during this time period. Median total and direct bilirubin were also calculated. The central lab pull identified 1726 patients who met these criteria since 2009, however most were duplicates. 254 unique patients were identified which gave an estimated prevalence of 0.027% of the population in Nova Scotia. The majority of our sample was female (82%) with a mean age 58.8 years (95%CI: 57.3–60.3 years). Median Alkaline Phosphatase was 161.5 units/L (133–256 units/L). All but two patients had a total bilirubin value with a median value 14 umol/L (IQR: 10–24 umol/L). Of these, 228 (90%) had a direct bilirubin available with a median of 5 umol/L (IQR: 3–12.5 umol/L). Our period prevalence estimate is consistent with other estimates that have been published in the current literature. Although the prevalence of PBC is low, many of these patients do not respond adequately to medical therapy and progress to need transplantation. New medical treatment modalities are needed for these patients and other trials are currently being performed. None
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".