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Record W2793231800 · doi:10.1016/j.autrev.2018.01.006

Bicaudal D2 is a novel autoantibody target in systemic sclerosis that shares a key epitope with CENP-A but has a distinct clinical phenotype

2018· review· en· W2793231800 on OpenAlexafffund
Marvin J. Fritzler, Marie Hudson, May Y. Choi, Michael Mähler, Mianbo Wang, Chelsea Bentow, Jay Milo, Murray Baron, Janet Pope, Janet Markland, David Robinson, Niall Jones, Nader Khalidi, Peter Docherty, Elżbieta Kamińska, Ariel Masetto, Evelyn Sutton, J.-P. Mathieu, Sophie Ligier, Tamara Grodzicky, Sharon LeClercq, Carter Thorne, Geneviève Gyger, D.P. Smith, Paul R. Fortin, Maggie Larché, Maysan Abu-Hakima, Tatiana Sofia Rodrı́guez-Reyna, Antonio R. Cabral

Bibliographic record

VenueAutoimmunity Reviews · 2018
Typereview
Languageen
FieldMedicine
TopicSystemic Sclerosis and Related Diseases
Canadian institutionsUniversité LavalHôpital Maisonneuve-RosemontDalhousie UniversityMoncton HospitalWestern UniversityUniversité de SherbrookeMcMaster UniversityUniversity of ManitobaUniversity of CalgaryMcGill UniversityJewish General HospitalUniversity of AlbertaUniversity of Saskatchewan
FundersCanadian Arthritis NetworkCanadian Institutes of Health ResearchNorman Cousins Center for PsychoneuroimmunologyScleroderma Society of OntarioJewish General HospitalDr. Fooke Laboratorien
KeywordsAutoantibodyEpitopeEpitope mappingBiologyAntibodyImmunology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesMeta-epidemiology (narrow), Research integrity
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.827
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.002
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0110.003
Bibliometrics0.0010.002
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0010.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.304
GPT teacher head0.388
Teacher spread0.085 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designOther design
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations27
Published2018
Admission routes2
Has abstractno

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