Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminating <i>Staphylococcus aureus</i>
Bibliographic record
Abstract
Significance Staphylococcus aureus is a bacterium causing many community-acquired skin infections. However, as dissemination from skin infections is rare, we were interested in understanding what mechanisms the body has in place to prevent escape of bacteria from skin infections via lymphatics to the rest of the body. We found that after infection, neutrophils were almost immediately recruited to the lymph nodes via specialized blood vessels to cut bacteria off at the pass. Neutrophils worked together with resident macrophages to prevent S. aureus spread, as removing both these immune cells from the lymph nodes resulted in bacterial dissemination to peripheral organs. This study demonstrates the importance of the lymph node neutrophils in early infection to prevent systemic dissemination of bacteria.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.003 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".