AB088. Quality of life and visual function in patients with Boston type I keratoprosthesis
Bibliographic record
Abstract
Background: To determine patient-reported vision-related quality of life (VR-QoL) following Boston type I keratoprosthesis (BI-KPro) surgery and its association with postoperative best-corrected visual acuity (BCVA). Methods: Descriptive cross-sectional study. Consecutive consenting patients with BI-KPro were included. The French National Eye Institute Visual Function Questionnaire-25 administered at 51±18 months postoperatively measured VR-QoL. Clinical charts were reviewed for demographics, indications for BI-KPro, baseline and postoperative (at time of interview) BCVA. For patients operated unilaterally, stratification of VR-QoL scores based on BCVA in the non-operated eye was performed. Multivariate linear regression was carried out, using VR-QoL scores as dependent variables, and demographics and postoperative BCVA as covariates. For patients operated bilaterally, Spearman correlation between VR-QoL scores and BCVA was performed. P<0.05 indicated statistical significance. Results: Sixty-four patients, aged 59±14 years, 52% male, with a follow-up of 54±19 months, were included. Postoperative BCVA increased from baseline in all operated eyes (P=0.000). In patients with unilateral BI-KPro (n=52), the VR-QoL overall score was 70.7±25.1. Scores on all questionnaire subscales were greater when BCVA in the non-operated eye was >20/200 compared to 20/200 (P=0.000). BCVA in the non-operated eye was positively associated with all subscales (P<0.01) independently of age, sex, follow-up duration and postoperative BCVA in the operated eye. In patients with bilateral BI-KPro (n=12) the VR-QoL overall score was 63.0±18.7. BCVA in the best eye positively correlated with Near/Distance activities, and social functioning subscales (P<0.05). There was no significant difference between VR-QoL scores of patients operated unilaterally vs. bilaterally. Conclusions: We describe VR-QoL more than 4 years after BI-KPro surgery. Compared to data at 1 year previously reported, our results suggest that, as vision progressively deteriorates in the operated eye, patients increasingly rely on their non-operated eye. VR-QoL after bilateral BI-KPro is assessed for the first time, and appears comparable to that after unilateral surgery. Larger, prospective, long-term studies, with assessment at baseline, are warranted.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".