Can Routine Use of Patient-Reported Outcomes Help Guide Systemic Sclerosis Chronic Disease Care?
Bibliographic record
Abstract
BACKGROUND: The implementation of patient reported outcome measures (PROMs) is increasingly recognized as a critical aspect of clinical practice. The use of PROMs is particularly important in patients with complex, chronic medical disease that have heterogeneous, subjective symptoms. In this report, we examine the association of traditional markers of disease severity in the systemic sclerosis (SSc) patient population with PROMs that focus on mental health and physical function. METHODS: SSc patients seen in the University of Utah Chronic Disease Clinic were offered a personal health assessment that included a current health visual analog scale (VAS), PROMs that assessed mental health [Patient-Reported Outcomes Measurement Information System (PROMIS) Bank v1.0 depression], and physical function (PROMIS Bank v1.2 physical function). All PROMIS instruments are normed such that an average person has a score of 50. The assessment was administered on a tablet while patients waited to see the physician(s) for SSc care visits and uploaded in real-time to the electronic medical record for physician review. RESULTS: During a six-month period, 137 unique SSc patients began a PROM assessment. All 137 patients completed the VAS and PROMIS physical function; 133 completed the PROMIS depression scales. Overall, scores were 53.1 and 43.2 for depression and physical function, respectively. Relatively mild patients without end-organ damage or disease activity due to SSc did not have significant differences in perceived reduction in general health, physical function, or depression when compared to SSc patients with digital ulcerations, interstitial lung disease, pulmonary arterial hypertension, inflammatory arthritis, inflammatory myositis, or joint contractures. CONCLUSIONS: Patients with chronic disease report depression and physical health scores that are independent of traditional physician-perceived disease activity or damage. Disease burden associates with the presence of a chronic disease, but is independent of severity. Assessment of PROMs provides an additional perspective on health status for chronic disease care.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.010 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".