P3273Aortic regurgitation and haemodynamic performance of a third-generation balloon-expandable transcatheter heart valve. Results from the SOURCE 3 registry echocardiographic substudy at 1 year
Bibliographic record
Abstract
Background: Transfemoral (TF- AVI) or trans-alternative access aortic valve implantation has become an accepted alternative treatment for aortic stenosis (AS) patients at intermediate/high/prohibitive risk for surgical replacement. Aortic regurgitation (AR ≥ moderate) after TAVI is a predictor of increased mortality and poor outcomes. The third-generation balloon-expandable transcatheter heart valve (THV) incorporates an outer sealing skirt designed to reduce moderate/severe paravalvular regurgitation. The SOURCE 3 Registry is a prospective post approval study including 80 European TAVI centres. Purpose: Our aim was to assess the haemodynamic performance of a third-generation THV and the subsequent stability of haemodynamic parameters in a subgroup of high-risk patients enrolled in the SOURCE 3 Registry. Methods: Echocardiographic examinations were performed at baseline, 30-day and 1-year follow-up post discharge and were interpreted by an independent central core laboratory. An analysis of haemodynamic parameters was conducted comparing discharge and 1 year. Results: The cohort included 276 prospectively enrolled patients with severe AS from 16 centres (TF-AVI: 241, 87.3%, aged 80.8±7.5 years, 54.3% men, mean logistic EuroSCORE: 15.6±10.6, NYHA III-IV: 71.3%). The mean aortic gradient decreased following the prosthesis implant and remained stable thereafter (change from discharge to 1 year: 1.0±5.4 mmHg). The aortic valve area increased significantly after implant and remained stable up to 1 year (Table). Most patients (82.1%) did not have AR (none or trace) at 1 year, 14.9% of patients harboured mild AR, 1.1% had mild/moderate, 1.7% moderate; none had severe AR. Similarly, the systolic and diastolic volumes and ejection fraction did not change (Table). The Kaplan Meier estimates at 1 year were 5.4% for all-cause mortality (3.1% cardiovascular mortality), 1.1% for disabling strokes, 0.7% for non-disabling strokes and 0.4% for transient ischemic attack.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".