2. Immunolocalization of Cystatin‐Related Epididymal Spermatogenic (CRES) Protein in Mouse Spermatozoa
Bibliographic record
Abstract
CRES is an inhibitor of a specific member of an enzyme family called serine proteases. It is thus thought to play a role in enzymatic regulation. It has been shown to be expressed only in the testes, epididymis, sperm, and gonadotropic cells of the anterior pituitary gland. Localization of CRES in sperm is an important step in determining its role within sperm. Previous studies have shown CRES to be localized in the mouse acrosomal cap: a vesicle on the tip of the sperm head which releases its contents upon initial sperm‐egg contact. The present study shows that developmental analysis of spermatogenesis via immunohistochemistry is incompatible with the conclusion that CRES is localized in the acrosomal cap. CRES expression begins in the elongating spermatid stage of sperm development; by this point, the acrosomal cap has been completed and it has never been shown that further additions to it can occur. Western blot and immunogold electron microscopy shows that CRES is localized in the sperm tail. It is also possible that further CRES is placed on the outer sperm membranes on the head as it travels through the epididymis, which is a part of the male reproductive tract.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".