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Reproducible evaluation of classification methods in Alzheimer's disease: Framework and application to MRI and PET data

2018· article· en· W2795824182 on OpenAlexfundno aff
Jorge Samper‐Gonzàlez, Ninon Burgos, Simona Bottani, Sabrina Fontanella, Pascal Lu, Arnaud Marcoux, Alexandre Routier, Jérémy Guillon, Michael Bacci, Junhao Wen, Anne Bertrand, Hugo Bertin, Marie-Odile Habert, Stanley Durrleman, Theodoros Evgeniou, Olivier Colliot

Bibliographic record

VenueNeuroImage · 2018
Typearticle
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsnot available
FundersNational Institute on AgingNational Institute of Biomedical Imaging and BioengineeringCanadian Institutes of Health ResearchEuropean Research CouncilSeventh Framework ProgrammeHorizon 2020 Framework ProgrammeGenentechNational Institutes of HealthInstitut de Cardiologie de MontréalUniversité Pierre et Marie CurieEisaiServierU.S. Department of DefenseEli Lilly and CompanyLundbeckfondenElanF. Hoffmann-La RocheAgence Nationale de la RechercheAssistance publique-Hôpitaux de ParisDoD Alzheimer's Disease Neuroimaging InitiativePfizerBioClinicaBiogenNovartis Pharmaceuticals CorporationBristol-Myers SquibbMerckAlzheimer's Drug Discovery FoundationGE HealthcareAlzheimer's Disease Neuroimaging InitiativeJohnson and JohnsonMeso Scale DiagnosticsIXICOTakeda Pharmaceutical CompanyAbbVieFujirebio EuropeAlzheimer's Association
KeywordsComputer scienceArtificial intelligencePreprocessorSupport vector machineRandom forestPattern recognition (psychology)Feature extractionMachine learningFeature (linguistics)SmoothingData miningComputer vision

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.088
metaresearch head score (Gemma)0.171
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Reproducibility · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.912
Threshold uncertainty score0.466

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0880.171
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0050.003
Science and technology studies0.0020.002
Scholarly communication0.0060.002
Open science0.0030.004
Research integrity0.0040.002
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.161
GPT teacher head0.502
Teacher spread0.340 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designSimulation or modeling
DomainReproducibility
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations178
Published2018
Admission routes1
Has abstractno

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