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Record W2799297366 · doi:10.1016/j.yrtph.2018.04.014

In silico toxicology protocols

2018· article· en· W2799297366 on OpenAlexaff
Glenn J. Myatt, Ernst Ahlberg, Yumi Akahori, David Allen, Alexander Amberg, Lennart T. Anger, Aynur O. Aptula, Scott S. Auerbach, Lisa Beilke, Phillip Bellion, Romualdo Benigni, Joel P. Bercu, Ewan D. Booth, Dave Bower, Alessandro Brigo, Natalie Burden, Zoryana Cammerer, M Cronin, Kevin P. Cross, Laura Custer, Magdalena Dettwiler, Krista L. Dobo, Kevin A. Ford, Marie Fortin, Samantha Gad-McDonald, Nichola Gellatly, Véronique Gervais, Kyle Glover, Susanne Glowienke, Jacky Van Gompel, Steve Gutsell, Barry Hardy, James Harvey, Jedd Hillegass, Masamitsu Honma, Jui-Hua Hsieh, Chia-Wen Hsu, Kathy Hughes, Candice Johnson, Robert A. Jolly, Davey L. Jones, Ray Kemper, Michelle Kenyon, Marlene T. Kim, Naomi L. Kruhlak, Sunil Kulkarni, Klaus Kümmerer, Penny Leavitt, Bernhard Majer, Scott A. Masten, Scott A. Miller, Janet Moser, Moiz Mumtaz, Wolfgang Muster, Louise Neilson, Tudor I. Oprea, Grace Patlewicz, Alexandre Tadeu Paulino, Elena Lo Piparo, Mark W. Powley, Donald P. Quigley, M. Vijayaraj Reddy, Andrea-Nicole Richarz, Patricia Ruiz, Benoı̂t Schilter, Rositsa Serafimova, Wendy Simpson, Lidiya Stavitskaya, Reinhard Stidl, Diana Suarez-Rodriguez, David T. Szabo, Andrew Teasdale, Alejandra Trejo‐Martin, Jean‐Pierre Valentin, Anna Vuorinen, B. Wall, Pete Watts, Angela White, Joerg Wichard, Kristine L. Witt, Adam Woolley, David Woolley, Craig Zwickl, Catrin Hasselgren

Bibliographic record

VenueRegulatory Toxicology and Pharmacology · 2018
Typearticle
Languageen
FieldVeterinary
TopicAnimal testing and alternatives
Canadian institutionsHealth Canada
FundersNational Institutes of HealthNational Institute of Environmental Health SciencesCoca-Cola Foundation
KeywordsIn silicoComputer scienceProtocol (science)Computational biologyRelevance (law)Reliability (semiconductor)Risk assessmentIdentification (biology)ToxicologyRisk analysis (engineering)BiologyMedicineGenetics

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.014
metaresearch head score (Gemma)0.017
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Protocol · Consensus signal: none
Teacher disagreement score0.034
Threshold uncertainty score0.115

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0140.017
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0030.002
Science and technology studies0.0020.002
Scholarly communication0.0040.003
Open science0.0070.005
Research integrity0.0030.004
Insufficient payload (model declined to judge)0.0340.020

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.148
GPT teacher head0.464
Teacher spread0.316 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreProtocol

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations241
Published2018
Admission routes1
Has abstractyes

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