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Record W2799321419 · doi:10.7939/r3891235d

Application of metabolomics to measure the Alberta “Foodome”

2017· article· en· W2799321419 on OpenAlexaboutno aff
Shima Borzouie

Bibliographic record

VenueUniversity of Alberta Library · 2017
Typearticle
Languageen
FieldMedicine
TopicNutritional Studies and Diet
Canadian institutionsnot available
Fundersnot available
KeywordsMeasure (data warehouse)Computer scienceData mining

Abstract

fetched live from OpenAlex

Food is fundamental to life. It is the source of essentially all the chemical and biological components found in our bodies. Given its importance, there is a growing desire among food producers, consumers, nutritionists, and dieticians to have a better understanding of the precise chemical content of foods. Unfortunately, the chemical composition of most foods is not well known. Indeed, standard food composition tables only provide data on a few dozen highly abundant chemicals. However, recent advances in analytical chemistry technologies and in the field of metabolomics now make it possible to identify and quantify thousands of compounds in biological matrices. These developments suggest that it may be possible to use metabolomics to more completely characterize the chemical constituents in food. The central objectives of my thesis are: 1) to apply modern quantitative metabolomic methodsto identify and quantify the chemical constituents and micronutrients in a select number of Alberta-grown vegetables, fruits, cereals and meats; and 2) to create a fully web accessible database that contains bothexperimentally derived values and literature-derived information on Alberta-grown foods, called the “Alberta Food Composition Database” (AFCDB: http://afcdb.ca). In working towards Objective #1, a combination of several modern metabolomics techniques, including ICP-MS, DFI-MS/MS, GC-MS, HPLC, and NMR were used to characterize the chemical constituents of nearly 40 different, Alberta-grown food products. Sample preparation, extraction, and separation techniques were developed or optimized to characterize amino acids, fatty acids, trace metals, vitamins, organic acids, phytochemicals, sugars, and lipids. ICP-MS assays generated composition data for up to 54 metal ions. DFI-MS/MS assay yielded data on about 50-110 compounds per food sample, whilethe GC-MS- ii based assays generated data for about 30-75 non-volatile compounds, 20-40 volatile compounds, and up to 20 fatty acids for each food sample. NMR assays yielded data on 30-50 compounds per food sample. Detailed literature mining led to the identification of up to 2000 more compounds for certain food products. By completing this study, I believe I have helped create perhaps the most comprehensive food information resource in the world. Through the AFCDB, Alberta producers have access to some of the most detailed and information-rich data on the food products they produce. This work could lead toa paradigm shift for food-health labeling, making Alberta food products uniquely appealing for health conscious consumers.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.398
Threshold uncertainty score0.827

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.208
Teacher spread0.194 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2017
Admission routes1
Has abstractyes

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