Bibliographic record
Abstract
Introduction: Plasmacytoid urothelial carcinoma (PUC) is a rare and aggressive variant of bladder cancer. Since PUC is infrequently encountered, its management continues to be a formidable challenge. Case 1: A 74-year-old gentleman was admitted with a 1-month history of gross hematuria and urinary overflow incontinence. Cystoscopy revealed an abnormal growth at the bladder base and biopsies were taken. This patient had high grade PUC sparing the muscularis propria (MP). He underwent nephrostomy tube insertion and subsequent conversion to internal stents 8 weeks later. Repeat resection showed muscle-invasive PUC. Repeat CT showed subcentimeter bilateral inguinal and external iliac lymphadenopathy. The surgeon discovered a dense infiltrative reaction within the retroperitoneum and colonic obstruction during radical cystoprostatectomy and palliative colostomy, confirming metastatic PUC. Case 2: A 72-year-old gentleman presented with gross hematuria, bleeding from an established end ileostomy, and bowel obstruction symptoms. Cystoscopy identified an anterior bladder tumour and CT staging confirmed a small bowel obstruction (SBO). Transurethral resection showed PUC with invasion of the MP and lymphovascular space. Obvious positive margins were identified during radical cystoprostatectomy, as the tumour clearly invaded bone and the rectal stump. Ileostomy output ceased post-operatively on day 4, and bowel contents began leaking through his urethra the following day. Reassessment of goals of care resulted in cessation of significant interventions. Unfortunately, he passed away 2 weeks post-operatively due to sepsis. Discussion: These cases illustrate the aggressiveness of PUC bladder tumours and how imaging frequently under-stages these patients. Neoadjuvant chemotherapy prior to attempting surgical control may be beneficial.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.003 | 0.003 |
| Science and technology studies | 0.003 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.003 | 0.003 |
| Research integrity | 0.007 | 0.003 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".