0969 Antidepressant Use Is Linked to Worse Sleep-Related Breathing Disturbances In People with Depressive Symptoms
Bibliographic record
Abstract
Serotonergic neurotransmission via the hypoglossal nerve plays an important role in the control of upper airway muscle tone and pharyngeal collapsibility during sleep. A limited number of studies have reported reductions in the apnea-hypopnea index following antidepressant intake in people with obstructive sleep apnea. Conversely, it has also been proposed that antidepressant use may actually exacerbate sleep-disordered breathing. Surprisingly little is known about these effects in people with depressive disorders. Therefore, this study assessed the effect of antidepressant use on sleep-related respiratory disturbances in individuals with depressive symptoms referred to a specialised sleep clinic. A retrospective polysomnography database from the sleep clinic of a mental health care facility was screened to identify individuals with a documented history of a unipolar depressive syndrome and current depressive symptoms of at least mild severity [Beck Depression Inventory-II (BDI) ≥ 14]. A sample of 839 patients meeting these criteria was divided into two groups based on antidepressant medication use at the time of polysomnography: the antidepressant group (n=581; 72% females, mean±SD: 45.8 ± 15.4 years old) and the no-antidepressant group (n=258; 69% females, mean±SD: 44.7 ± 15.4 years old). Respiratory disturbance indexes (RDIs) were compared across these groups. Compared to the no-antidepressant group, the antidepressant group had more severe depressive symptoms on the BDI (p<.001). There was no significant group difference in body mass index. After controlling for depression severity, the antidepressant group had a higher RDI than the no-antidepressant group (mean±SD: 25.2 ± 18.9 and 21.5 ± 15.7 respectively; F(1,836)=4.5, p =.034). As opposed to previous findings in non-depressed samples, antidepressant drugs are linked to worse sleep-related breathing disturbances in people with depressive symptoms and sleep complaints. Longitudinal studies are required to ascertain whether antidepressant drugs may interact with the pathophysiology of depression to play a causal role in respiratory abnormalities emerging during sleep. These findings may yield important insights for preventative and treatment strategies for sleep-related breathing disturbances in the context of depression. Support (If Any):
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".