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Record W2801254160 · doi:10.1016/j.jaci.2018.02.055

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects

2018· article· en· W2801254160 on OpenAlexaff
Charlotte Schwab, Annemarie Gabrysch, Peter Olbrich, Virginia Patiño, Klaus Warnatz, Daniel Wolff, Akihiro Hoshino, Masao Kobayashi, Kohsuke Imai, Masatoshi Takagi, Ingunn Dybedal, Jamanda Haddock, David M. Sansom, José Manuel Lucena, Maximilian Seidl, Annette Schmitt‐Graeff, Veronika Reiser, Florian Emmerich, Natalie Frede, Alla Bulashevska, Ulrich Salzer, Desirée Schubert, Seiichi Hayakawa, Satoshi Okada, Maria Kanariou, Zeynep Yesim Kucuk, Hugo Chapdelaine, Lenka Petruželková, Zdenĕk Šumnı́k, Anna Šedivá, Mary Slatter, Peter D. Arkwright, Andrew J. Cant, Hanns‐Martin Lorenz, Thomas Giese, Vassilios Lougaris, Alessandro Plebani, Christina Price, Kathleen E. Sullivan, Michel Moutschen, Jiří Litzman, Tomáš Freiberger, Frank L. van de Veerdonk, Mike Recher, Michael H. Albert, Fabian Hauck, Suranjith L. Seneviratne, Jana Pachlopnik Schmid, Antonios G.A. Kolios, Gary Unglik, Christian Klemann, Carsten Speckmann, Stephan Ehl, Alan M. Leichtner, Richard S. Blumberg, André Franke, Scott B. Snapper, Sebastian Zeißig, Charlotte Cunningham‐Rundles, Lisa Giulino‐Roth, Olivier Elemento, Gregor Dückers, Tim Niehues, Eva Froňková, Veronika Kanderová, Craig D. Platt, Janet Chou, Talal A. Chatila, Raif S. Geha, Elizabeth McDermott, Su Bunn, Monika Kurzai, Ansgar Schulz, Laia Alsina, Ferrán Casals, Àngela Deyà‐Martínez, Sophie Hambleton, Hirokazu Kanegane, Kjetil Taskén, Olaf Neth, Bodo Grimbacher

Bibliographic record

VenueJournal of Allergy and Clinical Immunology · 2018
Typearticle
Languageen
FieldImmunology and Microbiology
TopicImmunodeficiency and Autoimmune Disorders
Canadian institutionsCentre Hospitalier de l’Université de Montréal
FundersCilagMedical Research CouncilNational Institute of Allergy and Infectious DiseasesGrifolsMedacUniversität ZürichBundesministerium für Bildung und ForschungNational Institutes of HealthSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungUniversity of OxfordTherakosCrohn's and Colitis FoundationBiotechnology and Biological Sciences Research CouncilWellcome TrustJapan Blood Products OrganizationImmune Deficiency FoundationDeutsches Zentrum für InfektionsforschungBristol-Myers SquibbCSL BehringPfizerBiogenDeutsche ForschungsgemeinschaftGlaxoSmithKlineMinisterstvo Zdravotnictví Ceské RepublikyUniversity of Florida FoundationInstituto de Salud Carlos IIIAmgenNational Science Foundation
KeywordsCytotoxic T cellPenetrancePhenotypeImmunologyAntigenLymphocyteLymphocyte subsetsLymphocyte activationMedicineBiologyGeneticsImmune systemCD8T cellGeneIn vitro

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.285
Teacher spread0.266 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations441
Published2018
Admission routes1
Has abstractno

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