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Record W2801312275 · doi:10.1016/j.cell.2018.03.029

The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression

2018· article· en· W2801312275 on OpenAlexafffund
Shadrielle M. G. Espiritu, Lydia Liu, Yulia Rubanova, Vinayak Bhandari, Erle M. Holgersen, Lesia Szyca, Natalie S. Fox, Melvin L.K. Chua, Takafumi N. Yamaguchi, Lawrence E. Heisler, Julie Livingstone, Jeff Wintersinger, Fouad Yousif, Emilie Lalonde, Alexandre Rouette, Adriana Salcedo, Kathleen E. Houlahan, Constance H. Li, Vincent Huang, Michael Fraser, Theodorus van der Kwast, Quaid Morris, Robert G. Bristow, Paul C. Boutros

Bibliographic record

VenueCell · 2018
Typearticle
Languageen
FieldMedicine
TopicProstate Cancer Treatment and Research
Canadian institutionsVector InstituteToronto General HospitalUniversity of TorontoUniversity Health NetworkPrincess Margaret Cancer CentreOccupational Cancer Research CentreOntario Institute for Cancer Research
FundersNatural Sciences and Engineering Research Council of CanadaCanadian Cancer SocietyProstate Cancer CanadaCanada First Research Excellence FundGovernment of OntarioCompute CanadaCanadian Institutes of Health ResearchGenome CanadaGovernment of CanadaOntario Institute for Cancer ResearchTerry Fox Research InstituteMovember Foundation
KeywordsBiologyProstate cancerProstateCancer researchPoint mutationCancerOncologyGeneMutationInternal medicineGeneticsMedicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.009
Threshold uncertainty score0.030

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0090.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.029
GPT teacher head0.363
Teacher spread0.335 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations271
Published2018
Admission routes2
Has abstractno

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