In perfusion imaging–selected acute ischemic stroke, thrombectomy at 6 to 16 hours improved functional outcomes
Bibliographic record
Abstract
ACP Journal Club17 April 2018In perfusion imaging–selected acute ischemic stroke, thrombectomy at 6 to 16 hours improved functional outcomesOmar Damji, MSc, MD, Eddy Lang, MDOmar Damji, MSc, MDCumming School of Medicine, University of Calgary, Calgary, Alberta, Canada (O.D., E.L.)Search for more papers by this author, Eddy Lang, MDCumming School of Medicine, University of Calgary, Calgary, Alberta, Canada (O.D., E.L.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2018-168-8-042 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationAlbers GW, Marks MP, Kemp S, et al; DEFUSE 3 Investigators. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med. 2018;378:708-18. https://pubmed.ncbi.nlm.nih.gov/29364767Clinical Impact RatingsEmergency Med: Hospitalists: Neurology: References1 Powers WJ, Derdeyn CP, Biller J, et al; American Heart Association Stroke Council. 2015 American Heart Association/American Stroke Association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015;46:3020-35. [PMID: 26123479] Google Scholar2 Phan K, Dmytriw AA, Maingard J, et al. Endovascular thrombectomy alone versus combined with intravenous thrombolysis. World Neurosurg. 2017;108:850-8.e2. [PMID: 28823660] Google Scholar3 Nogueira RG, Jadhav AP, Haussen DC, et al; DAWN Trial Investigators. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018;378:11-21. [PMID: 29129157] Google Scholar4 Sevick LK, Ghali S, Hill MD, et al. Systematic review of the cost and cost-effectiveness of rapid endovascular therapy for acute ischemic stroke. Stroke. 2017;48:2519-26. [PMID: 28716983] Google Scholar Author, Article, and Disclosure InformationAffiliations: Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada (O.D., E.L.)This article was published at Annals.org on 3 April 2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 April 2018Volume 168, Issue 8Page: JC42KeywordsBrainHemorrhagic strokeInfarctionIschemic strokeMagnetic resonance imagingNeuroimagingNeurologyNumber needed to treatRisk ratioStroke ePublished: 17 April 2018 Issue Published: 17 April 2018 Copyright & PermissionsCopyright © 2018 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.015 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.002 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.042 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".