0938 Fear of Sleep (FS) in Posttraumatic Stress Disorder (PTSD) Patients Correlates Directly with Indices of Hyperarousal During Wakefulness and Sleep
Bibliographic record
Abstract
Fear of sleep (FS) can be a significant factor in the sleep disturbances encountered in PTSD. PTSD patients may experience FS due to several reasons including fear of losing vigilance, fear of experiencing traumatic nightmares and a conditioned association of bedtime with traumatic experiences (eg., sexual abuse). We examined some psychologic and sleep physiologic correlates of FS. 40 consenting civilians with PTSD (38 female, mean±SD age: 44.60 ± 12.73) underwent ≥1 nights of Level 3 home sleep testing (WatchPAT200; Itamar Medical, Israel)(average scores from 3 nights of sleep data from 33/40 patients are presented in this report) and completed a battery of instruments including the Fear of Sleep Inventory (FOSI))(Zayfert et al., 2006), a 23-item instrument where participants rate trauma-related sleep disturbances involving fear of sleep, Insomnia Severity Index (ISI) and PTSD Checklist for DSM-5 (PCL-5). The mean±SD PCL-5 score was 40.40 ± 18.81 (cutoff for PTSD at 33). FOSI scores were directly correlated with total PCL-5 (Pearson r=0.639, p<0.001) score and its symptom subscales of Cluster B(intrusive symptoms) (r=0.605,p<0.001), Cluster C (avoidance) (r=0.577,p<0.001), Cluster D(negative cognitions) (r=0.493, p=0.002) and Cluster E(hyperarousal) (r=0.654, p<0.001), and the ISI (r=0.548,p<0.001). Multiple regression analysis using FOSI score as dependent variable and all PCL5 subscales and ISI as independent variables, revealed that only PCL-5 Cluster E (β =0.648,t=4.959, p<0.001) remained a significant predictor of FOSL in the regression model (adjusted R2=0.403 for this model). The FOSI correlated with several sleep physiological measures as follows: sleep latency (r=0.620, p<0.001), mean pulse rate during sleep (r=0.492, p=0.004), sleep efficiency (r=-0.547,p=0.001), no. wakenings/hour (r=0.353, p=0.044), respiratory disturbance index (r=0.480,p=0.003) and oxygen desaturation index (r=0.593,p<0.001). FS may be an index of the underlying drive for vigilance and sympathetic activation in PTSD patients both during wakefulness and sleep. The previously unreported finding of a direct correlation of FS with indices of sleep-disordered breathing and heart rate during sleep, in addition to measures of sleep fragmentation, further supports this. None.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".