Bibliographic record
Abstract
The moss Physcomitrella patens was originally chosen for the study of gene regulation in plant development Its gametophyte generation is haploid and exhibits an ordered sequence of developmental transitions facilitating the isolation and identification of mutants. The physiology associated with this sequence had been partially characterised in the closely related Funaria hygrometrica and, for example, shown to involve auxin [2] and cytokinin P. patens was preferred to F. hygrometrica because of the invaluable preliminary studies of Engel [4] and the short, approximately 8-week life cycle of P. patens in laboratory conditions. Consequently, pioneers of the P. patens plant model system envisaged using classical forward genetics for the dissection of developmental processes. Since protonemal tissue, the first tissue to be formed from a germinating moss spore, can be propagated vegetatively, the culture of mutants that were abnormal even at an early stage of development presented no problems-although when such mutants were sterile, orthodox genetic analysis was not possible. To circumvent this problem, somatic hybrids were made by protoplast fusion Perhaps the most complete early example of this forward genetics approach involved 15 sterile gametophore overproducing (ove) mutants Somatic hybridisation demonstrated that the ove phenotype is recessive in all but one case, and the ratio of mutant to wild-type postmeiotic segregants from self-fertilised hybrids was consistent with the altered phenotype being the result of a single mutation in each case tested. Recessive mutants were assigned to three complementation groups (oveA, B, and C) and the ratio of ove to wild-type segregants from a selfed oveA/oveB somatic hybrid showed that the two affected genes are unlinked The biochemical basis for the ove phenotype is an increased level of biologically active cytokinins, principally N 6 -( 2 -isopentenyl) adenine [8, 9]. However, mapping the ove mutations and identifying the genes affected and their corresponding proteins have yet to be achieved.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".